A ranking of the saddest Grey’s Anatomy character deaths

After 15 seasons, the long-running medical drama “Grey’s Anatomy” has lost a lot of characters.

Longtime fans of the show know that showrunner Shonda Rhimes has never been afraid to write off a character, whether it be a case-of-the-week patient or a leading doctor. And it’s not just that these characters die, it’s that they oftentimes pass in devastating, tragic ways that leave viewers heartbroken.

Here is a ranking of some of the most tragic deaths on “Grey’s Anatomy.” Although the show has many character deaths, this list focuses on some of the most major and memorable ones.